Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine
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چکیده
James K. Hennan, Jinbao Huang, Terrance D. Barrett, Edward M. Driscoll, David E. Willens, Andrew M. Coronary Arteries Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc3301.09279
منابع مشابه
Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.
BACKGROUND Prostanoid synthesis via the action of cyclooxygenase-2 (COX-2) is a component of the inflammatory response. Prostacyclin, a product of COX-2 in vascular endothelium, has important physiological roles, such as increasing blood flow to injured tissues, reducing leukocyte adherence, and inhibiting platelet aggregation. We examined the possibility that selective COX-2 inhibition could s...
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This study was designed to determine the effect of inhibitors of cyclooxygenase (COX)-1, COX-2, and the nonselective COX inhibitor naproxen on coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide (LPS)-induced inflammatory conditions. We hypothesize that endothelial COX-1 is the primary COX isoform in the canine normal coronary artery, which mediates arachidonic acid ...
متن کاملEffects of the Cyclooxygenase Inhibition on Canine Coronary Artery Blood Flow and Thrombosis
This study was designed to determine the effect of inhibitors of COX-1, COX-2 and the nonselective COX inhibitor, naproxen on, coronary vasoactivity and thrombogenicity under baseline and lipopolysaccharide-induced inflammatory conditions. We hypothesize that; endothelial COX-1 is the primary COX isoform in the canine normal coronary artery, which mediates arachidonic acid-induced vasodilatatio...
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Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
متن کاملSelective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships
Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The therapeutic anti-inflammatory action of NSAIDs is produced by the inhibition of COX-2, while the ...
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تاریخ انتشار 2001